Does Vitamin E interact with Vitamin K2 MK-7?

Written to our editorial standards · reviewed against published research· Updated 6 Jun 2026
Check with a clinician· moderate evidence

High-dose vitamin E can work against vitamin K.

At high doses, vitamin E can interfere with vitamin K and its role in clotting, which may increase bleeding tendency, especially alongside blood thinners. At normal supplemental doses the interaction is minor.

What to do

Keep vitamin E to a sensible dose (a few hundred IU of mixed tocopherols, not mega-doses). Taking K2 for bone or heart reasons is fine, but tell your doctor about both if you use any blood thinner or face surgery.

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Vitamin E
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Vitamin K2 MK-7
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Common questions

Can I take Vitamin E and Vitamin K2 MK-7 together?
Check with a clinician. Keep vitamin E to a sensible dose (a few hundred IU of mixed tocopherols, not mega-doses). Taking K2 for bone or heart reasons is fine, but tell your doctor about both if you use any blood thinner or face surgery.
Why do Vitamin E and Vitamin K2 MK-7 interact?
At high doses, vitamin E can interfere with vitamin K and its role in clotting, which may increase bleeding tendency, especially alongside blood thinners. At normal supplemental doses the interaction is minor.

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Educational use only, not medical advice. Interaction risk depends on dose, your health, and any medications. Always consult a qualified clinician, especially if you take prescription drugs or are pregnant or nursing.