Best time to take Glycine

Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Before bed

Take glycine about 30 to 60 minutes before bed for sleep.

Glycine is a calming neurotransmitter that gently lowers core body temperature, a signal that helps you fall asleep and improves sleep quality, which is why a bedtime dose makes the most of it.

When
Take before bed
With food?
With or without food
Typical dose
3 g
How to take it

Take around 3 g before bed. It dissolves easily in water and tastes slightly sweet, so it is easy to take last thing at night.

Watch out

There is little reason to take it in the morning.

Full guide
Glycine: benefits, dose & evidence
Read the ingredient guide →

Common questions

When is the best time to take Glycine?
Take glycine about 30 to 60 minutes before bed for sleep. Take around 3 g before bed. It dissolves easily in water and tastes slightly sweet, so it is easy to take last thing at night.
Should I take Glycine with or without food?
With or without food. Glycine is a calming neurotransmitter that gently lowers core body temperature, a signal that helps you fall asleep and improves sleep quality, which is why a bedtime dose makes the most of it.
Anything to watch out for with Glycine timing?
There is little reason to take it in the morning.

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Educational use only, not medical advice. The right timing and dose depend on your health, your other supplements, and any medications. Always consult a qualified clinician, especially if you take prescription drugs or are pregnant or nursing.