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ANTIOXIDANTS

Apigenin (Parsley Extract)

Sleep · CD38 inhibition · longevity

MODERATE EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
QUICK ANSWER

Apigenin: Sleep · CD38 inhibition · longevity. A flavonoid that inhibits CD38 (preserving NAD+), binds GABA receptors for sleep, and shows anti-inflammatory effects. Standard dose 50 mg, taken in the evening, about $22/month. Evidence rating: moderate evidence.

What is Apigenin?

Apigenin is a plant flavonoid found in chamomile, parsley, celery, and artichokes. It works through multiple mechanisms: as a partial agonist at GABA-A receptors (promoting calm and sleep), as a CD38 inhibitor (preserving NAD+ levels), and as an anti-inflammatory antioxidant. Apigenin is part of the well-known evening protocol of longevity researcher Dr. David Sinclair, who reports taking 50 mg before bed. Human evidence is limited to small trials, but its safety profile, low cost, and synergy with NAD+ precursors make it a popular addition to longevity stacks. Standard dose is 50 mg before sleep.

WHY IT MATTERS

A flavonoid that inhibits CD38 (preserving NAD+), binds GABA receptors for sleep, and shows anti-inflammatory effects.

Natural food sources

Where possible, get Apigenin from whole foods first. Common dietary sources include:

ParsleyCeleryChamomile teaArtichokes

Where to buy

Double Wood Apigenin 50mg
RECOMMENDED
Double Wood, Apigenin
50 mg · Evening · ~$22/month

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Stacks that include Apigenin

∞
The Longevity Blueprint
The frontier protocol for slower biological aging.

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Common questions

What is Apigenin?
Apigenin is a plant flavonoid found in chamomile, parsley, celery, and artichokes. It works through multiple mechanisms: as a partial agonist at GABA-A receptors (promoting calm and sleep), as a CD38 inhibitor (preserving NAD+ levels), and as an anti-inflammatory antioxidant. Apigenin is part of the well-known evening protocol of longevity researcher Dr. David Sinclair, who reports taking 50 mg before bed. Human evidence is limited to small trials, but its safety profile, low cost, and synergy with NAD+ precursors make it a popular addition to longevity stacks. Standard dose is 50 mg before sleep.
What is Apigenin used for?
Sleep · CD38 inhibition · longevity. A flavonoid that inhibits CD38 (preserving NAD+), binds GABA receptors for sleep, and shows anti-inflammatory effects.
What is the standard dose of Apigenin?
50 mg, typically taken in the evening. Approximate cost is $22 per month.
How strong is the evidence for Apigenin?
Moderate evidence for its primary uses. See the full study list on the research page.

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