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Pterostilbene

Sirtuin activation · cognition · longevity

MODERATE EVIDENCEVEGANREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
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Pterostilbene: Sirtuin activation · cognition · longevity. A more bioavailable and longer-lasting cousin of resveratrol. Activates sirtuins and supports memory and metabolic health. Standard dose 100 mg, taken in the morning, about $28/month. Evidence rating: moderate evidence.

What is Pterostilbene?

Pterostilbene is a methylated analog of resveratrol found primarily in blueberries. Its two methyl groups give it roughly 4× the bioavailability and significantly longer half-life than resveratrol while activating the same sirtuin longevity pathways. Human trials show benefits for blood pressure, cholesterol, and self-reported cognitive performance. The patented pTeroPure form, made by ChromaDex via fermentation, is the most-researched commercial source. Standard dose is 50-250 mg per day, often stacked with NAD+ precursors. Pterostilbene has GRAS status from the FDA.

WHY IT MATTERS

A more bioavailable and longer-lasting cousin of resveratrol. Activates sirtuins and supports memory and metabolic health.

Natural food sources

Where possible, get Pterostilbene from whole foods first. Common dietary sources include:

BlueberriesGrapesCranberries

Where to buy

Life Extension Pterostilbene 100mg
RECOMMENDED
Life Extension, Pterostilbene
100 mg · Morning · ~$28/month

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Stacks that include Pterostilbene

∞
The Longevity Blueprint
The frontier protocol for slower biological aging.

Best for your goal

Interactions

Other antioxidants

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Inflammation · joint · recovery
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Cellular energy · heart
Alpha-Lipoic Acid (ALA)
Antioxidant · blood sugar · nerve health
Quercetin (with Bromelain)
Immune · allergies · circulation

Common questions

What is Pterostilbene?
Pterostilbene is a methylated analog of resveratrol found primarily in blueberries. Its two methyl groups give it roughly 4× the bioavailability and significantly longer half-life than resveratrol while activating the same sirtuin longevity pathways. Human trials show benefits for blood pressure, cholesterol, and self-reported cognitive performance. The patented pTeroPure form, made by ChromaDex via fermentation, is the most-researched commercial source. Standard dose is 50-250 mg per day, often stacked with NAD+ precursors. Pterostilbene has GRAS status from the FDA.
What is Pterostilbene used for?
Sirtuin activation · cognition · longevity. A more bioavailable and longer-lasting cousin of resveratrol. Activates sirtuins and supports memory and metabolic health.
What is the standard dose of Pterostilbene?
100 mg, typically taken in the morning. Approximate cost is $28 per month.
How strong is the evidence for Pterostilbene?
Moderate evidence for its primary uses. See the full study list on the research page.

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