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GUT & DIGESTIVE

Tributyrin (Butyrate)

Gut lining · short-chain fatty acid · inflammation

MODERATE EVIDENCEREAD THE RESEARCH
Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Last reviewed: May 30, 2026
QUICK ANSWER

Tributyrin: Gut lining · short-chain fatty acid · inflammation. A precursor to butyrate, the primary fuel for colon cells. Supports gut barrier integrity and reduces inflammation. Standard dose 1500 mg, taken in the morning, about $38/month. Evidence rating: moderate evidence.

What is Tributyrin?

Butyrate is a short-chain fatty acid produced when gut bacteria ferment dietary fiber, and it is the preferred energy source for colon cells (colonocytes). Adequate butyrate supports the gut barrier, reduces low-grade inflammation, and is increasingly linked to immune and even cognitive function via the gut-brain axis. Many modern diets are too low in fermentable fiber to produce sufficient butyrate. Tributyrin is a triglyceride form of butyrate that survives stomach acid and releases butyrate directly in the colon, far more effective than sodium butyrate. Standard dose is 500-2000 mg per day with food.

WHY IT MATTERS

A precursor to butyrate, the primary fuel for colon cells. Supports gut barrier integrity and reduces inflammation.

Natural food sources

Where possible, get Tributyrin from whole foods first. Common dietary sources include:

ButterGheeParmesan cheeseFermented fiber-rich foods

Where to buy

BodyBio Butyrate (Tributyrin)
RECOMMENDED
BodyBio, Tributyrin
1500 mg · Morning · ~$38/month

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Common questions

What is Tributyrin?
Butyrate is a short-chain fatty acid produced when gut bacteria ferment dietary fiber, and it is the preferred energy source for colon cells (colonocytes). Adequate butyrate supports the gut barrier, reduces low-grade inflammation, and is increasingly linked to immune and even cognitive function via the gut-brain axis. Many modern diets are too low in fermentable fiber to produce sufficient butyrate. Tributyrin is a triglyceride form of butyrate that survives stomach acid and releases butyrate directly in the colon, far more effective than sodium butyrate. Standard dose is 500-2000 mg per day with food.
What is Tributyrin used for?
Gut lining · short-chain fatty acid · inflammation. A precursor to butyrate, the primary fuel for colon cells. Supports gut barrier integrity and reduces inflammation.
What is the standard dose of Tributyrin?
1500 mg, typically taken in the morning. Approximate cost is $38 per month.
How strong is the evidence for Tributyrin?
Moderate evidence for its primary uses. See the full study list on the research page.

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