Tributyrin (Butyrate)
Gut lining · short-chain fatty acid · inflammation
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What is Tributyrin?
Butyrate is a short-chain fatty acid produced when gut bacteria ferment dietary fiber, and it is the preferred energy source for colon cells (colonocytes). Adequate butyrate supports the gut barrier, reduces low-grade inflammation, and is increasingly linked to immune and even cognitive function via the gut-brain axis. Many modern diets are too low in fermentable fiber to produce sufficient butyrate. Tributyrin is a triglyceride form of butyrate that survives stomach acid and releases butyrate directly in the colon, far more effective than sodium butyrate. Standard dose is 500-2000 mg per day with food.
A precursor to butyrate, the primary fuel for colon cells. Supports gut barrier integrity and reduces inflammation.
Natural food sources
Where possible, get Tributyrin from whole foods first. Common dietary sources include:
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