Supplements for low mood

Written to our editorial standards · reviewed against published research· Updated 2 Jun 2026
Mood & stress

Low mood is commonly associated with low vitamin D, omega-3, B12, and folate; these support the brain chemistry behind mood regulation.

Vitamin D receptors sit throughout the brain and low levels are repeatedly linked to low mood, especially in darker months. The omega-3 EPA is the form studied for mood, and B12 and folate are needed to make serotonin and to keep homocysteine, which is associated with depression, in range.

Nutrients commonly linked

Vitamin D3 + K2
See the guide →
Omega-3 Fish Oil
See the guide →
Methyl-B12
See the guide →
Methylfolate
See the guide →
Saffron Extract
See the guide →

Biomarkers worth checking

These are the blood tests most relevant here. Knowing your numbers tells you whether a supplement is the right answer.

Vitamin D (25-OH)Vitamin B12FolateHomocysteine
When to see a doctor

If low mood lasts more than two weeks, affects daily life, or includes thoughts of self-harm, contact a doctor or a crisis line now. Supplements are not a substitute for care.

Beyond supplements

Daylight, exercise, sleep, and social connection have strong evidence for mood and pair well with addressing any deficiency.

Common questions

What supplements help with low mood?
Low mood is commonly associated with low vitamin D, omega-3, B12, and folate; these support the brain chemistry behind mood regulation. The nutrients most often linked are Vitamin D3 + K2, Omega-3 Fish Oil, Methyl-B12, Methylfolate, Saffron Extract.
Which deficiencies are associated with low mood?
Vitamin D receptors sit throughout the brain and low levels are repeatedly linked to low mood, especially in darker months. The omega-3 EPA is the form studied for mood, and B12 and folate are needed to make serotonin and to keep homocysteine, which is associated with depression, in range.
When should I see a doctor about low mood?
If low mood lasts more than two weeks, affects daily life, or includes thoughts of self-harm, contact a doctor or a crisis line now. Supplements are not a substitute for care.

Explore further

Find out what's actually low

Upload your bloodwork and we'll read the relevant markers, or take the quiz for a personalised stack.

Analyse my bloodwork →Take the quiz

Educational use only, not medical advice, diagnosis, or treatment. Symptoms have many possible causes, and the nutrients here are commonly associated with this symptom, not a guaranteed fix. Always consult a qualified clinician, especially if symptoms are severe, persistent, or new.