Folate: what it means.

B-vitamin needed for DNA synthesis and methylation.

Written to our editorial standards · reviewed against published research· Updated 27 Jun 2026
Typical reference bands (ng/mL)
Lowunder 4 ng/mL
Optimal7-20 ng/mL
Ranges vary by laboratory, age, and sex, your lab's own reference range always takes precedence.
What does low folate mean?Causes, symptoms & what to do →

Common causes

  • Low intake of leafy greens and legumes
  • Regular alcohol use
  • Pregnancy, which raises demand
  • MTHFR variants that slow activation of folic acid

What it can feel like

  • Fatigue
  • Mouth sores
  • Low mood
  • In pregnancy, a higher neural-tube-defect risk

Who should test

Relevant before and during pregnancy, with heavy alcohol use, or alongside an elevated homocysteine.

Supplements that help raise Folate

Evidence-led, and only a piece of the picture, diet, lifestyle, and your clinician matter most.

Methylfolate is the active form the body uses directly, useful for those with MTHFR variants who convert folic acid poorly.

Shop the top pick for folate
Thorne 5-MTHF 1mg
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Thorne, 5-MTHF 1mg
60 capsules · ~$20 · ★ 4.8

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Common questions

What does a low Folate mean?
Common drivers include low intake of leafy greens and legumes; regular alcohol use; pregnancy, which raises demand. A result outside the optimal range is best read in context: discuss it with your clinician, who can weigh the full picture and your lab's own reference range.
What supplements help raise Folate?
Evidence-led options include Methylfolate, B-Complex. They support, but don't replace, diet, lifestyle, and medical care.

Educational use only, not medical advice or diagnosis. Always interpret lab results with a qualified clinician.